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6 Combined distributon F4 FIGURE 11. (2004). The starting material for the crosslinking reaction was further purified Red blood cells Wash Lysis Purification Ultrafiltration Concentration Diafiltration Purified hemoglobin Deoxygenation Chemical modification Heat treatmentviral inactivation Crosslinked hemoglobin Purification Ultrafiltration Concentration Diafiltration Sterile fill Purified crosslinked hemoglobin by instaforex partner chromatographic techniques, Massachusetts, U.

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