Thus, vacation) Structural or Functional Disorders Colonic obstruction Neoplasm, volvulus, inflammation (diverticulitis), ameboma, tuberculosis, syphilis, lymphogranuloma venereum, ischemic colitis, anastomotic stricture, endometriosis Diverticular disease Anorectal outlet obstruction Anal obstruction (stenosis, fissure) Rectocele Spastic pelvic floor syndrome (anismus) Visceral neuropathy or myopathy Congenital aganglionosis (Hirschsprungs disease) Acquired aganglionosis (Chagas disease) Slow-transit constipation (colonic inertia) Megarectum (sometimes with megacolon) Chronic intestinal pseudo-obstruction Acute Intestinal pseudo-obstruction (Ogilvies Syndrome) Irritable bowel syndrome (visceral hypersensitivity) Neurologic Abnormalities (Outside Colon) Central nervous system (cerebral neoplasm, Parkinsons disease) Trauma Spinal cord (neoplasm, multiple sclerosis) Defective innervation (resection of nervi erigentes) Psychiatric Disorders Depression Psychoses Anorexia nervosa Iatrogenic Causes Medication (codeine, antidepressants, iron, anticholinergics) Immobilization Endocrine and Metabolic Causes Hypothyroidism Hypercalcemia Pregnancy Diabetes mellitus Dehydration Hypokalemia Uremia Pheochromocytoma Hypopituitarism Lead poisoning Porphyria Mucoviscidosis Aganglionosis, whether it occurs congenitally in pati- ents with Hirschsprungs disease or is acquired because of the neurotoxin of Trypanosoma cruzi, will cause constipation.
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